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Cyclessa

Oral contraceptives come in a variety of formulations. The main division is between combined oral contraceptive pills, containing both estrogen and progesterone, and progesterone only pills (mini-pills). Combined oral contraceptive pills also come in varying types, including varying doses of estrogen, and whether the dose of estrogen or progesterone changes from week to week. more...

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Combined oral contraceptive pills

All contain the estrogen ethinyl estradiol, although in varying amounts, and one of a number of different progesterones. They are taken for 21 days with then a 7 day gap during which a withdrawal bleed (often, but incorrectly, referred to as a menstrual period) occurs. These differ in the amount of estrogen given, and whether they are monophasic (only one dose of estrogen and progesterone during the 21 days) or multiphasic (varying doses).

Monophasic

These are given as 21 tablets of estrogen and progesterone, followed by 7 tablets of placebo. Different formulations contain different amounts of estrogen and progesterone:

20 mcg estrogen
- 0.1 mg levonorgestrel (Alesse®, Levline®)
- 1 mg norethindrone acetate (Loestrin 1/20®Fe)
30 mcg estrogen
- 0.15 mg levonorgestrel (Levlen®, Levora®, Nordette®)
- 0.3 mg norgestrel (Lo-Ovral®)
- 0.15 mg desogestrel (Desogen®, Organon; Ortho-Cept®, Ortho-McNeil)
- 1.5 mg norethindrone acetate (Loestrin® 1.5/30)
- 3.0 mg drospirenone (Yasmin®)
35 mcg estrogen
- 0.25 mg norgestimate (Ortho-Cyclen®)
- 0.4 mg norethindrone (Ovcon-35®, Warner Chilcott)
- 0.5 mg norethindrone (Modicon®, Brevicon®)
- 1 mg norethindrone (Ortho-Novum 1/35®, Necon®, Norethin®, Norinyl 1/35®)
- 1 mg ethynodiol diacetate (Demulen 1/35®, Zovia 1/35E®)
50 mcg estrogen
- 0.4 mg norethindrone (Ovcon-50®, Warner Chilcott))
- 1 mg norethindrone (Necon 1/50®, Norinyl 1/50®, Ortho-Novum 1/50®, Ovcon-50®)
- 0.5 mg norgestrel (Ovral®)
- 1 mg ethynodiol diacetate (Demulen 1/50®, Zovia 1/50E®)

Multiphasic

Desogestrel 0.15 mg and ethinyl estradiol 0.02 mg x 14 tablets, followed by ethynil estradiol 0.01 mg x 2 tablets, followed by 5 tablets of placebo (Kariva®, Barr Laboratories; Mircette®, Organon)
Desogestrel 0.1 mg ethynil estradiol 0.025 mg x 7 tablets, followed by desogestrel 0.125 mg and ethynil estradiol 0.025 mg x 7 tablets, followed by desogestrel 0.15 mg and ethynil estradiol 0.025 mg x 7 tablets, followed by 7 tablets of ferric oxide (Cyclessa®, Organon; Velivet®, Barr Laboratories)
Norethindrone 0.5 mg and ethinyl estradiol 0.035 mg x 7 tablets, followed by 0.75 mg of norethindrone and 0.035 mg of ethinyl estradiol x 7 tablets, followed by 1 mg of norethindrone and 0.035 of ethinyl estradiol, followed by 7 tablets of placebo (Ortho-Novum 7/7/7®)
Norethindrone 0.5 mg and 0.035 mg of ethinyl estradiol x 10 tablets, followed by 1 mg norethindrone and 0.035 ethinyl estradiol x 11 tablets, followed by 7 tablets of placebo (Ortho-Novum 10/11®)

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Prasco Ships Cesia Oral Contraceptive Tablets; Prasco Will Market the Triphasic Oral Contraceptive Desogestrel/Ethinyl Estradiol Tablets Under the Name
From Business Wire, 9/16/04

CINCINNATI -- Prasco Laboratories

Cesia is AB-Rated and therapeutically equivalent to the brand Cyclessa(R)

Prasco Laboratories, a privately-held pharmaceutical company located in Cincinnati, Ohio, announced today it has begun shipping its new oral contraceptive Cesia(TM)(1) (desogestrel/ethinyl estradiol) Tablets. Cesia (pronounced SESH-ah) is a Prasco Authorized Generic oral contraceptive, AB-Rated and therapeutically equivalent to the brand Cyclessa(R)(2) from Organon. Cesia will compete for generic sales with one other generic triphasal desogestrel/ethinyl estradiol oral contraceptive product in this market segment.

"Prasco is in the business of marketing Prasco Authorized Generics," said Prasco Chief Executive Officer E. Thomas Arington, "and our business model was developed to encourage more competition and innovations that meet market demands, which should ultimately benefit consumers through cost savings," said Arington.

Cesia tablets are presented in a hard, compact case and are packaged three units to a box.

"Cesia's three-unit packaging configuration was designed with our customers in mind. This pharmacy friendly package of three compacts will provide pharmacists more flexibility--regarding inventory and shelf space--than the other generic in this market segment," said Arington. "In addition, Cesia's compact case is identical to the brand product, which we believe is preferred by women over a blister-card wallet. Prasco Authorized Generics benefit the entire pharmaceutical supply chain because we supply brand quality at generic prices," Arington concluded.

About Prasco

Founded by Arington in 2002, Prasco's mission is to provide both quality products and significant cost-savings to the consumer. Prasco is a leading multi-source marketing company that utilizes a versatile, horizontally-integrated business approach. This strategy allows Prasco to combine its intellectual property with the special capabilities of selected partners to realize opportunities and benefit consumers by finding and filling unmet needs within the pharmaceutical marketplace.

Prasco's goal is to lead the field in Prasco Authorized Generics, which are brand products sold under the Prasco private label. Prasco's executive team has extensive experience working within both the brand and generic industries. A centerpiece of the company's corporate capabilities is its sales/marketing and business development teams. Prasco's product line is currently sold through the major distribution channels, including chains, independent pharmacies, distributors, wholesalers, and managed care providers.

The company operates from a 54,000 sq. ft. administrative office and warehouse facility and has complete control over product distribution management systems--including DEA-approved facilities for Schedule II-V controlled drug products.

(1) Cesia(TM) is a trademark of Prasco, LLC.

(2) Cyclessa(R) is a registered trademark of Organon N.V. Organon, OSS The Netherlands

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