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Cylert

Pemoline (sold as Cylert®) is a medication used to treat attention-deficit hyperactivity disorder (ADHD). Under the Convention on Psychotropic Substances, it is a Schedule IV drug . more...

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Pemoline has some advantages over other stimulants in that it doesn't reduce the appetite or cause dry mouth. However, in some patients Pemoline is suspected of causing liver damage, so regular liver tests are performed are those treated with it. Since receiving FDA aproval in 1975, it has been linked with 21 cases of liver failure, of which 13 resulted in liver replacement or death. In 2005, the FDA withdrew approval for Pemoline due to pressure from certain public advocacy groups. Patient support group the Narcolepsy Network tried to persuade the FDA not to ban it, on the grounds that some patients find all other treatments ineffective or to have dehabilitating side effects. The medication was used by an estimated 10,000 Americans afflicted with narcolepsy.

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Heads up - adverse effects of Cylert
From Inside MS, 9/22/99

Do you take Cylert (pemoline)?

Cylert helps relieve "nonexertional" MS fatigue--the exhaustion that comes out of the blue for many people with MS. The FDA originally approved the medication in 1975 as a treatment for childhood Attention Deficit Hyperactivity Disorder, or ADHD. Like many other medications used for MS symptoms, Cylert is prescribed "off-label"--meaning that the FDA has not reviewed data on its effectiveness for this use.

Cylert is in the news today Since 1975, the FDA has received reports that 15 children taking Cylert have had sudden acute liver failure. The FDA is now requiring Abbott Laboratories, manufacturer of Cylert, to recommend a liver function evaluation every two weeks.

The National MS Society's Medical Advisory Board examined this issue carefully. There is no record of a single person with MS experiencing liver failure from taking Cylert, although the drug is widely prescribed for people with MS. The children are given far larger doses than are given for MS fatigue. The Medical Advisory Board does not consider the findings in these children a reason for adults with MS to stop using Cylert if it is effective in reducing their fatigue. But liver failure is a serious matter.

If you take Cylert for MS fatigue and experience

* loss of appetite

* yellowing of the skin or whites of the eyes (jaundice)

* nausea

contact your prescribing physician without delay. Ask your health-care provider if you have any concerns about Cylert--especially if you take other medications with the potential for affecting the liver.

Are you eligible for veterans benefits?

Army? Navy? Air Force? Marines? Coast Guard? U.S. veterans who were diagnosed with MS during their military service or up to 7 years after being honorably discharged may be eligible for disability compensation and other benefits from the Department of Veterans Affairs.

For more information, or to get assistance filing a benefits claim, contact PVA (the Paralyzed Veterans of America): 801 18th Street NW, Washington, DC 20006; 800-232-1782, or call your nearest Veterans Administration Regional Office, 800-827-1000.

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